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Top 5 DNA Insights Everyone Over-40 Should Know for Vibrant Aging  

Because aging well isn’t about luck—it’s about alignment. Your genes hold the blueprint, however your choices hold the power. And when you match your lifestyle to your DNA, vibrant health becomes your new normal.

Backed by peer-reviewed science, nutrigenomics, and clinical research—including the work of Dr. Ben Lynch, Dr. Margaret Smith, and discoveries from the Human Genome Project—these discoveries are here to help you live longer, stronger and more adventurously.

1. Methylation Matters (MTHFR & Friends)

Your methylation genes (like MTHFR, MTRR, and COMT) help your body process B vitamins, detoxify hormones and toxins, and keep your mood and brain function stable.

🧬 If these genes are slow or impaired:

🎯 Why it matters after 40: Poor methylation = faster aging, poor energy, and sluggish detox. DNA testing helps you support these genes for vitality, mood balance, and hormonal harmony—key pillars of preventative health.

🔍 Referenced: NIH – MTHFR polymorphisms and chronic disease risk; Lynch, B. (2018) Dirty Genes.

2. Your Inflammation Genes Can Be Calmed

Genes like TNF-alpha, IL-6, and CRP affect your body’s inflammatory response. If you have high-expression variants, you may be more prone to:

🎯 Why it matters after 40: Chronic, low-grade inflammation is behind most age-related diseases. Knowing your genetic tendencies helps you eat, move and supplement in ways that cool the fire—not fuel it. This is one of the core foundations of healthy aging.

🔍 Referenced: Harvard Health; Smith, M. et al. (SmartDNA) on inflammatory SNPs and chronic illness.

3. How You Metabolise Fats Affects Everything

Your APOE, FTO and PPAR genes influence how well your body processes fats—and how those fats affect your brain, weight and heart health.

🧬 Some people thrive on olive oil and avocado—others may struggle to clear cholesterol or gain weight easily.

🎯 Why it matters after 40: These discoveries help you personalise your fats and oils (including omega-3s) for a sharper brain, healthier weight and a stronger heart. Tailoring your nutrition to your DNA helps reduce guesswork and optimise your longevity.

🔍 Referenced: JAMA Neurology on APOE and Alzheimer’s risk; PPAR alpha studies on lipid metabolism.

4. Histamine Intolerance May Be in Your Genes

If you have variations in genes like DAO or HNMT, your body may not break down histamine effectively. That can cause reactions to:

🎯 Why it matters after 40: Histamine overload can mimic food sensitivities, cause migraines and amplify hormonal symptoms. DNA discoveries help you lower your histamine load and feel calmer, clearer and more balanced—essential for emotional wellbeing and vibrant aging.

🔍 Referenced: European Journal of Clinical Nutrition; DAO gene and histamine intolerance.

5. Your Detox Pathways May Need Extra Support

Your GST, NAT, CYP, and SULT genes control how you clear toxins, hormones, medications and even caffeine.

🧬 If your detox genes are slow or overworked:

🎯 Why it matters after 40: You’re more exposed to toxins and less efficient at clearing them. Supporting your detox genes helps protect your hormones, skin, weight and long-term wellness—especially if you're focused on prevention and aging well.

🔍 Referenced: Institute for Functional Medicine; Dr. Mark Hyman on Phase I/II detox and gene-environment interaction.

🔬 Ready to Find Out What Your DNA Says?

You’re not guessing anymore. With a SmartDNA Genomic Wellness Test and personalised consultations at Radiate Wellness, you’ll discover:

👉 Click here to explore what the SmartDNA Genomic Wellness Test is all about—how it works, what it reveals and why it's the game-changer in preventative health and vibrant aging.

📝 Or take the quiz here to see if your DNA might be calling for support—especially if you’re already living a 'healthy' lifestyle but still feeling off. 


Because your genes spark the story—but your lifestyle shapes the ending.

Now let’s make the second half of your life the most vibrant adventure yet.